In recent years, advances in research suggest major therapeutic advances in the field of mental health. We have a better understanding of triggers, including environmental triggers. We have better prevention techniques and new therapies. New molecules have been developed as well as psychoeducation programs like cognitive remediation. The list of achievements as well as the needs is long.
The Foundation contributes to these advances by awarding grants, promoting collaborative work between both public and private teams of researchers and health care providers and by co-financing programs validated by its independent scientific advisors. More than one million euros has been spent on Foundation social programs, including: nine research programs, ten scholarships, prizes and various grants.


"DBS and depression" : a research program supported by the foundation



This program aims to study the potential benefits of deep brain stimulation in resistant depression.

Emilie Lacombe under the direction of Thérèse Jay and Bruno Millet

Depression is the fourth leading cause of disability in the world because of its significant human and socio-economic implications. Frequently encountered in clinical contexts, the phenomenon of drug-resistant depression (DRT) concerns 50% to 60% of depressed patients for whom antidepressant treatments remain ineffective. This represents a real challenge in terms of public health. Budget : 72 184 €


"Recent data suggest that the dysfunction of some neural circuitry is involved in DRT, and deep brain stimulation (DBS) at high frequency could be an adaptable and reversible therapeutic solution to modulate these circuits. Among the various DBS targets tested, the ventral striatum, or nucleus accumbens (NAc), has shown particularly promising effects. This project is inspired by a French multicenter clinical study (STHYM), coordinated by Pr. Bruno Millet. The objective is to develop DBS NAc as a treatment for DRT.

The first phase of the project funded by the Pierre Deniker Foundation is to validate the potential beneficial effects of chronic DBS NAc in a known model of DRT (tested on Wistar-Kyoto rats) on cognitive and emotional deficits commonly seen in depression. The preliminary data obtained show an improvement in mnemic anhedonia and deficits characteristic of depression. The project nevertheless represents a long process. We plan to add more complex behavioral tasks to confirm these encouraging results.

Later, we will explore DBS action mechanisms with the help of positron emission tomography with fludeoxyglucose (18F) (FDG-PET) to identify changes in metabolic activity in neural networks involved in depression and also in an animal model of depression. Further experiments will assess the potential effects of DBS on synaptic plasticity and expression of synaptic markers in different cortico-limbic regions involved in depression. These approaches provide neurobiological evidence we can correlate to the potential beneficial effect of DBS on cognitive and / or emotional deficits."

Emilie Lacombe



PROFAMILLE : a program for relatives of a patient with schizophrenia.


ProFamille Ile-de FranceThe objective of this program is to address the sense of powerlessness that the patient and his or her family may feel when coping with the disease. Families often have conceptions of disease that are far from reality. Correcting these misconceptions can help to better handle stressful situations in the family, and gain a better understanding of the pathology and the care system relating to it. Thus the practical implementation of the program rests on two pillars: the first is a system of information on disorders, symptoms and their treatment. The second involves learning techniques to better cope with difficult situations and sources of stress encountered daily.



The ICAAR Study : from psychotic transition to adolescence.


This project is targeted at identifying predictors of events related to disabling psycho-behavioral disorders that could disrupt the educational, emotional or social trajectory of young adults. It includes subjects who are faced with minor symptoms to assess and monitor their progress in implementing recommended drug, psychological or social therapies. The study is conducted at the University Hospital Service of Sainte-Anne Hospital in Paris. Budget:  66,000 € over three years.

FILHARMONIE: the first research and prevention program for young adults.


 The mental health of students can be weakened by stress periods marking the end of high school curriculum or the passage from the more restrained world of high school to the more open world of the university. The student must increasingly put into action his capabilities for autonomy, forge new relationships, and tackle more solitary work arrangements than in the context of a high school class ...


In partnership with the Health Foundation of French Students, the Pierre Deniker Foundation offers support to teachers who have identified a student in difficulty through a hotline to give advice and the appropriate answers or guidance to address the problem. The rector of Paris is the first partner to support this effort. Others will be online tomorrow. Budget: 30,000 €




Created in 2012, the Institute of Psychiatry - 3557 GDR has a mission to promote and support collaborative international and joint projects with the involvement of 21 teams including 15 official founding teams spread over the entire country. Five working groups were formed that work on 4 themes:


Inhibitory control and executive functions, sensorimotor integration and social interactions, hallucinations / self-perception, diagnosis and innovative therapies. Besides these research programs, the Institute of Psychiatry organizes forums, training sessions aimed at psychiatry professionals or patients and their families.